The article titled “Metabolic Assessment of Human Induced Pluripotent Stem Cells-Derived Astrocytes and Fetal Primary Astrocytes: Lactate and Glucose Turnover” was published in Biosensors today.
Astrocytes are one of the key cell types in brain for energy metabolism. In this research article, the metabolic parameters of astrocytes derived from two common sources including induced pluripotent stem cells (hiPSCs) and human fetal primary astrocytes (HFAs) were studied in a defined media. The glucose uptake and lactate production in astrocytes derived from hiPSC to HFA were compared using a flow-through biosensor. The study concluded that hiPSC-derived astrocytes are as glycogenic as their fetal counterparts, but their normalized metabolic turnover is lower.